Chlorhexidine Reduces the Rate of CVC-Associated BSIs

In a prospective, multicenter trial, daily body cleansing with 2% chlorhexidine was associated with a significant reduction in central venous catheter bloodstream infections.

One proposed way to decrease the number of catheter-related bloodstream infections (BSIs) is to reduce skin contamination in patients with these devices. Chlorhexidine reduces both resident and transient bacterial flora on the skin, with a residual effect lasting ≥6 hours. Several previous studies have suggested that bathing with a chlorhexidine solution reduces the rate of BSIs in hospitalized patients.

To further examine this possibility, investigators conducted a prospective, multihospital study in which they assessed the effect of daily cleansing with chlorhexidine on the rate of central venous catheter (CVC)–associated BSIs. During a 6- to 9-month preintervention phase, patients were bathed without chlorhexidine. Then, during an 8-month…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)