Antibiotic Concentrations During Continuous Renal Replacement Therapy

In critically ill patients receiving such therapy, trough levels of antibiotics showed wide variability, unrelated to effluent flow rate.

Continuous renal replacement therapy (CRRT) is widely used for treatment of severe acute renal insufficiency in critically ill patients. In this situation, antibiotic elimination can be influenced by patient factors, as well as by drug factors and CRRT technique. Determining the right dose and dosing interval is a challenge. How often are therapeutic concentrations missed under such conditions?

To find out, researchers in Australia measured ciprofloxacin, meropenem, piperacillin/tazobactam, and vancomycin trough levels in critically ill adults with acute kidney injury who were receiving continuous venovenous hemodiafiltration at effluent flow rates of 25 or 40 mL/kg/hour. Dosing was at the discretion of the treating physician, was determined…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection