Hyperglycemia Is Associated with Poorer Outcomes Among Patients with Sepsis

Among nondiabetic patients with sepsis admitted to a non-ICU hospital unit, in-hospital mortality rose and hospital length of stay increased as blood glucose concentrations increased.

Studies performed in the intensive care unit (ICU) setting suggest that controlling blood glucose leads to improved outcomes. Whether this is true in the non-ICU setting and whether there is a difference between patients with and without diabetes is unclear.

To explore this issue, researchers performed a secondary analysis of a prospective, observational cohort study involving adults who received treatment for suspected sepsis in the emergency department of a large medical center in Boston and were then admitted to a non-ICU ward of the same hospital. Between December 2003 and September 2004, 1849 patients were enrolled, of whom 539 (29%) had preexisting diabetes.

The mean time-weighted glucose concentration during the first 72 hours after ad…

Reviewing Author

Neil M. Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Hyperglycemia Is Associated with Poorer Outcomes Among Patients with Sepsis

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Reviewing Author