Update on the Outbreak of Fungal Meningitis Associated with Contaminated Methylprednisolone

The index case that led to the recognition of the outbreak is described, and what is currently known about the outbreak is detailed in a preliminary report.

A new report provides details on the index case in the recent outbreak of fungal meningitis associated with contaminated methylprednisolone injections.

An immunocompetent man in his 50s presented with headache and neck pain; 4 weeks earlier, he had received a lumbar epidural injection of methylprednisolone. Although computed tomography of the head was unrevealing, cerebrospinal fluid (CSF) analysis showed neutrophilic pleocytosis and marked hypoglycorrhachia. One of several CSF samples grew Aspergillus fumigatus. Despite antifungal therapy, the patient developed seizures, and his mental status declined. Further neuroimaging revealed evidence of a mycotic aneurysm and cerebral and cerebellar infarcts. The patient died on hospital day 22, afte…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)