The Burden and Etiology of Childhood Diarrhea in Asia and Africa

Targeting five pathogens — rotavirus, Cryptosporidium, Escherichia coli (enterotoxigenic and enteropathogenic), and Shigella — could substantially reduce the burden of childhood diarrhea in developing countries.

Worldwide, diarrhea accounts for about 10% of all deaths in children aged <5 years. The prospective, case-control Global Enteric Multicenter Study was designed to better define the burden and etiology of diarrheal disease in infants and young children in sub-Saharan Africa and South Asia.

Between December 2007 and March 2011, children aged ≤59 months treated for new-onset, moderate-to-severe diarrhea at sentinel health centers were enrolled, each along with one to three randomly selected matched controls (total, 9439 cases and 13,129 controls). Using standardized methods across sites in seven countries, investigators collected clinical and epidemiologic data and fecal samples and followed up about 60 days later.

Four pathogens — rotavirus, Cr…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

The Burden and Etiology of Childhood Diarrhea in Asia and Africa

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Reviewing Author