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Some strains of Staphylococcus aureus remain susceptible to classic penicillin, with the proportion varying by geographic region. Is penicillin the best treatment for infections caused by such pathogens, as is suggested by ex vitro data indicating a superior potency of penicillin over penicillinase-resistant β-lactams?
To answer this question, researchers conducted a retrospective analysis involving adult patients with penicillin-susceptible S. aureus bacteremia at six hospitals in Denmark over a 5-year period. Of these 588 patients, 92% received empirical antibiotic treatment within 1 day of blood culture. By days 3 and 4, 77% and 93% of patients, respectively, were on definitive antimicrobial treatment: penicillin in 28%, dicloxacillin in …