Loading...
The optimum target blood pressure in patients with hypertension is unknown, and the role of aspirin in such patients is controversial. In the Hypertension Optimal Treatment (HOT) study, 18,790 patients with hypertension from 26 countries were randomly assigned a target diastolic blood pressure of less than or equal to 90 mm Hg, 85 mm Hg, or 80 mm Hg.
Felodipine was given as the initial baseline therapy. Additional therapy included sequential addition of either an angiotensin-converting enzyme (ACE) inhibitor or a beta-blocker; dosage titration of felodipine from 5 to 10 mg/day; doubling the dose of either the ACE inhibitor or beta-blocker; and, as a last step, the addition of a diuretic. Patients in each target group were randomized to recei…