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Nonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most frequently prescribed medications and also are widely available over the counter. When one considers this and the high prevalence of hypertension, it is reasonable to expect that instances of concomitant use of NSAIDs and antihypertensive medications will occur. NSAIDs are known to reduce the effectiveness of some antihypertensive medications, but whether the new angiotensin II receptor antagonists also are affected by NSAIDs is unclear.
These researchers conducted a randomized, double-blind, multicenter study to assess the impact of indomethacin on the antihypertensive effects of the angiotensin II receptor antagonist losartan and the ACE inhibitor captopril. After a 4-week …