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Instead of using preventive drug therapy to target individual coronary and stroke risk factors in people with the highest risk levels, what if we could target several risk factors simultaneously in everyone at increased risk? To achieve this ambitious end, British researchers propose a theoretical combination pill that would simultaneously target cholesterol, blood pressure, serum homocysteine, and platelet function -- regardless of pretreatment levels -- in people age 55 or older.
On the basis of data from many randomized drug trials (about 400,000 total patients), including data from 2 accompanying meta-analyses, the researchers propose a daily pill containing 6 drugs: a statin (10-mg atorvastatin, 40-mg simvastatin, or 40-mg lovastatin); …