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Some heart-failure patients have depressed left ventricular ejection fractions (LVEFs), and some do not. Although these two groups exhibit similar clinical signs and symptoms, they differ in other respects. For example, those with preserved LVEFs tend to be older and to have hypertension, LV hypertrophy, marked exercise intolerance, and high rehospitalization rates. To identify mortality predictors in patients with LVEFs >45%, researchers analyzed data from 988 such patients in the Digitalis Investigation Group (DIG) trial who were in sinus rhythm and had symptoms of clinical heart failure.
A multivariable analysis identified several significant predictors of 3-year mortality, including lower glomerular filtration rate, NYHA class III-IV sta…