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About 30% of patients in heart failure (HF) registries have renal insufficiency. Even mild to moderate insufficiency (creatinine clearance [CrCl], 40-60 mL/minute) is associated with increased mortality risk in men with systolic dysfunction. Given that mortality risk factors are less well documented in women with HF, researchers retrospectively analyzed data on renal insufficiency from 2734 postmenopausal women with known coronary artery disease and body-mass indexes ≥18.5 kg/m2 in the Heart and Estrogen Replacement Study (HERS).
About 700 women had histories of HF or developed it during the study; women with either preserved or reduced LV ejection fractions (LVEFs) were included. Baseline CrCl levels (in mL/minute) were >60 in 43% of the wo…