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Some studies have identified Chlamydia pneumoniae in atherosclerotic tissue and have documented an association between this infection and adverse cardiovascular events. However, a recent meta-analysis of randomized trials of various antichlamydial antibiotics in patients with established heart disease found no significant benefit during short-term follow-up, usually less than 2 years (Journal Watch Cardiology Jul 8 2005). Now, researchers in Denmark have randomized 4373 patients with stable heart disease to receive clarithromycin (500 mg/day) or placebo for 2 weeks. All had been diagnosed with MI or angina pectoris from 1993 through 1999. Follow-up lasted up to 3 years.
Incidence of the primary composite endpoint (death, MI, or unstable angi…