A Stepwise Approach to NSAID Use

Given their cardiovascular risks, COX-2 inhibitors should be a last resort for managing musculoskeletal pain.

Sponsoring Organization

American Heart Association

Background

Evidence that selective COX-2 inhibitors, a type of nonsteroidal anti-inflammatory drug (NSAID), increase the risk for serious cardiovascular events has led to a cascade of drug warnings, safety advisories, and even withdrawals from the market. The lingering issue for practitioners has been to pinpoint the appropriate clinical roles for specific NSAIDs and other pain relievers. Now, the AHA has issued a scientific statement on NSAID use for patients with, or at high risk for, heart disease. The statement places management of musculoskeletal pain in a broader context, synthesizes recent evidence on pharmacologic treatment options, and proposes a stepwise approach to treatment.

Key Con…

Reviewing Author

Joel M. Gore, MD

A Stepwise Approach to NSAID Use

Topics

Reviewing Author