RethinQ-ing Resynchronization Therapy in Patients with Narrow QRS

In a randomized trial, patients with narrow QRS complexes and evidence of mechanical dyssynchrony did not benefit from CRT.

Cardiac resynchronization therapy (CRT) has been shown to relieve symptoms in patients with NYHA class III heart failure and QRS durations of ≥130 ms. This benefit is thought to relate to the elimination of mechanical dyssynchrony, which can improve cardiac output. A wealth of data supports the hypothesis that mechanical dyssynchrony is a better predictor of improvement with CRT than is electrical dyssynchrony (i.e., a wide QRS complex). In addition, results from single-center case–control studies have suggested that CRT benefits patients with QRS intervals of <120 ms and evidence of mechanical dyssynchrony (Journal Watch Cardiology Jan 10 2007). In the manufacturer-supported RethinQ study, investigators randomized 172 patients with newly-i…

Reviewing Author

Mark S. Link, MD

Disclosures

Editorial BoardsCirculation; UpToDate

Mark S. Link, MD

Disclosures

Editorial BoardsCirculation; UpToDate

RethinQ-ing Resynchronization Therapy in Patients with Narrow QRS

Topics

Reviewing Author