In a large population study, considering measures of fat distribution as well as measures of BMI increased prognostic accuracy.
As girth increases in the general population, how various measures of adiposity relate to risk for death is emerging as an important question in formulating clinical recommendations. To address this issue, investigators for the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort study, assessed the association of body-mass index, waist circumference, and waist-to-hip ratio with the risk for death in individuals from nine European countries.
EPIC’s study population includes men and women aged 25 to 70 at enrollment (mean age at baseline, 51.5; 65% women). Of the 359,387 participants included in this analysis, 14,723 died during a mean follow-up of 9.7 years.
The lowest risk for death was found at BMIs of 25.3 in…
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DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association