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Several data sets have associated genetic variants at chromosome 9p21.3 with cardiovascular disease. In the Women’s Genome Health Study, a prospective genetic evaluation study involving participants in the Women’s Health Study, initially healthy U.S. women were followed for a median of 10 years for incident cardiovascular events.
A total of 22,129 white women were genotyped for the analysis. Of these, 26.2% had no risk alleles at rs10757274 (AA), 49.5% were heterogeneous for the risk allele (AG), and 24.3% were homogeneous (GG). The number of risk alleles was significantly associated with family history of premature MI. The adjusted hazard ratio of incident cardiovascular events associated with the polymorphism was 1.25 for the AG genotype a…