Predictors of Early Stent Thrombosis

Among several disease-and procedure-related culprits, suboptimal antiplatelet use might be the easiest target for improving outcomes after stenting.

In this substudy of the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial, investigators sought to identify predictors of stent thrombosis (ST) in 3405 moderate- and high-risk patients with acute coronary syndromes. All participants received at least one stent (89% drug-eluting) and underwent quantitative coronary angiography before and after stent implantation.

Early ST (within 30 days postimplantation) occurred in 48 patients (1.4%) a median of 5 days after implantation. Patients with definite (n=32) or probable (n=16) ST had high rates of death (27%) and MI (79%). The rate of early ST was similar in drug-eluting and in bare-metal stent recipients.

Renal insufficiency and diabetes requiring insulin were more commo…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI

Leadership Positions in Professional SocietiesHeart Valve Collaboratory (Scientific Committee Member, Chair of the Publications Committee)