According to a meta-regression analysis, interventions that modify HDL levels do not reduce risk for CHD.
HDL levels show a strong inverse correlation with risk for coronary heart disease. Whether increasing HDL levels translates into better clinical outcomes, however, remains unproven. To find out if changes in HDL levels are associated with changes in outcomes, investigators used meta-regression methods to analyze the results of 108 randomized trials.
The analysis included 146,890 patients in intervention groups and 152,420 in control groups; all trials reported changes in HDL and LDL levels and clinical outcomes. The most common interventions were statins (62 trials), fibrates (9 trials), ω-3 fatty acids (9 trials), and hormones (9 trials). The weighted mean decrease in LDL was 23.0 mg/dL, and the mean increase in HDL was 1.7 mg/dL.
After adju…
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DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association
DisclosuresConsultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime
EquityHugo Health; Refactor Health; Element Science
Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association