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In 2003, Wald and Law proposed that combining low-dose antihypertensives, a statin, aspirin, and folic acid could substantially reduce cardiovascular events (JW Cardiol Aug 22 2003). But would combining multiple agents into one pill diminish their pharmacologic effects? To find out, investigators for The Indian Polycap Study (TIPS) compared the effects of Polycap — a combination of thiazide (12.5 mg), atenolol (50 mg), ramipril (5 mg), simvastatin (20 mg), and aspirin (100 mg) — with those of 8 individual and variously combined formulations of its components on LDL levels, blood pressure, pulse rates, urinary 11-dehydrothromboxane B2 levels, and rate of treatment discontinuation. This manufacturer-sponsored, factorial, randomized trial incl…