Insulin-Induced Hypoglycemia and Mortality After Acute MI

Observational data suggest that spontaneously occurring hypoglycemia is more ominous than hypoglycemia that occurs after insulin treatment.

Controversy surrounds the use of insulin for glucose control in patients with hyperglycemia after acute MI, because some data have suggested that hypoglycemia in these patients is associated with increased mortality. In this retrospective analysis of 7820 patients hospitalized for acute MI between January 1, 2000, and December 31, 2005, investigators assessed whether hypoglycemia, occurring either spontaneously or after insulin administration, is associated with increased in-hospital mortality. All subjects had glucose levels ≥140 mg/dL on admission.

Overall in-hospital mortality was significantly higher in patients who developed hypoglycemia than in those who did not. However, mortality in insulin-treated patients who developed hypoglycemia…

Reviewing Author

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

JoAnne M. Foody, MD

Disclosures

Consultant / Advisory boardAegerion; Amarin; Bristol-Myers Squibb; Janssen; Merck; Pfizer; Sanofi-Aventis; Boehringer Ingelheim

Leadership positions in professional societiesAmerican College of Cardiology, Cardiosmart (Co-chair)

Insulin-Induced Hypoglycemia and Mortality After Acute MI

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Reviewing Author