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Patients with resistant hypertension — elevated blood pressure that persists despite the use of three or more antihypertensive agents — are frequently encountered in clinical practice. To examine the role of salt sensitivity in resistant hypertension, investigators conducted a randomized crossover evaluation of two 7-day diets, one low-sodium (50 mmol/day) and one high-sodium (250 mmol/day), separated by a 2-week washout period. Twelve adults (mean age, 56; 8 women; 6 black patients) completed the study. At baseline, participants were taking an average of 3.4 antihypertensive medications, and the mean office blood pressure was 145.8/83.9 mm Hg. All participants continued taking their medications during the study.
Mean urinary sodium excretio…