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Findings from several studies have suggested that the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) reduce the risk for cardiovascular events. To find out whether low doses of EPA/DHA (400 mg/day), ALA (2 g/day), or both, provided in margarine, would reduce rates of cardiovascular events, investigators for the multicenter, double-blind, placebo-controlled Alpha Omega trial — a 2×2 factorial design with EPA/DHA and ALA — recruited 4837 older patients (mean age, 69; 78% men) who had survived a myocardial infarction (MI) within the previous 10 years. Eighty-six percent of enrolled patients were receiving lipid-lowering agents, primarily …