A Randomized Comparison of Drug-Eluting and Bare-Metal Stents in Large Coronary Vessels

At 2 years of follow-up, DES were as good as BMS at preventing cardiovascular death and nonfatal MI in vessels ≥3 mm in diameter.

Many interventional cardiologists use bare-metal stents (BMS) in large coronary arteries to minimize the possible risk for late stent thrombosis associated with drug-eluting stents (DES), reserving DES for small vessels to minimize the risk for target-vessel revascularization (TVR). To compare the risks and benefits of DES and BMS in large coronary arteries, investigators for the European BASKET-PROVE study randomized 2314 patients requiring stents between 3 and 4 mm in diameter to receive first-generation sirolimus-eluting stents (SES), second-generation everolimus-eluting stents (EES), or cobalt-chromium BMS. Thirty-two percent of participants had ST-segment-elevation myocardial infarction (MI), 43% had multivessel disease, and 76% had an…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI

Leadership Positions in Professional SocietiesHeart Valve Collaboratory (Scientific Committee Member, Chair of the Publications Committee)

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Leadership Positions in Professional SocietiesHeart Valve Collaboratory (Scientific Committee Member, Chair of the Publications Committee)