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Often, a substudy provides valuable insights that complement the initial trial findings. Sometimes, however, you need to look closely to identify the additional insight.
As reported in 2007 in the New England Journal of Medicine, 2287 patients with objective evidence of myocardial ischemia and significant epicardial coronary artery disease were randomized to receive either optimal medical therapy (OMT) alone or percutaneous coronary intervention (PCI) plus OMT. During a median follow-up of 4.6 years, incidence of the primary endpoint — death or nonfatal myocardial infarction (MI) — was statistically similar in the two groups, but slightly higher with PCI than with OMT alone (19.0% vs. 18.5%; P=0.62). PCI also showed…