Menopause Increases Risk for Recurrent Syncope in Women with Long-QT Syndrome, Type 2

Female sex is a risk factor for arrhythmic events in individuals with long-QT syndrome (LQTS), a congenital disorder with two common genotypes (LQT1 and LQT2). According to previous studies, women with LQTS, particularly those with LQT2, are at heightened risk for events during adolescence and postpartum (JW Cardiol Apr 11 2007). Now, investigators have studied data from the LQTS Registry to assess the effects of menopause on the risk for events in both genotypes. The sample included 151 women with LQT1 and 131 women with LQT2, all aged ≥30. Follow-up time was divided into three prespecified periods: reproductive (up to 5 years before menopause onset), transitional (the 5 years before and including menopause onset), and postmenopausal (up t…