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Angina in the absence of obstructive coronary artery disease (CAD) can result from microvascular coronary dysfunction, is more common in women than in men, and is associated with increased morbidity and mortality (JW Cardiol Jun 10 2009). To evaluate the safety of invasive coronary reactivity testing in this situation, investigators at three centers participating in the WISE study administered intracoronary adenosine, acetylcholine, and nitroglycerin while measuring coronary flow velocity with a Doppler guide wire in the left anterior descending arteries of 293 women (mean age, 54; 84% white) with symptomatic ischemia and without obstructive CAD. Baseline risk factors included smoking (48%), dyslipidemia (32%), hypertension (35%), and diabe…