Association of Post-PCI Bleeding and In-Hospital Mortality

In a large registry study, the link was strongest in patients at high preprocedure bleeding risk and those with non–access-site bleeding.

Assessment of the relationship between bleeding and post-percutaneous coronary intervention (PCI) mortality is hampered by overlapping patient variables that may predict both events. In an analysis of data from the national CathPCI Registry, investigators examined more than 3.3 million procedures performed between 2004 and 2011 and identified 57,246 major bleeding events (1.69%) and 22,165 in-hospital deaths (0.65%). Major bleeding was defined as the need for transfusion, prolonged hospital stay, or a decrease in hemoglobin of more than 3.0 g/dL.

Unadjusted in-hospital mortality was higher in patients with than in those without major bleeding complications (5.6% vs. 0.6%; P<0.001). In a propensity-matched analysis, bleeding remained associat…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI