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Fluoroquinolones, such as ciprofloxacin, are extensively used in the treatment of a broad range of infectious diseases. Since they are relatives of nalidixic acid, it is not surprising that fluoroquinolones have photosensitizing potential. The photosensitivity of ciprofloxacin has been previously demonstrated in vitro. The current study assessed the in vitro photosensitivity of norfloxacin and the clinical photosensitivity of both norfloxacin and ciprofloxacin. The in vitro studies used five experimental model systems, and the clinical studies used extensive, controlled monochromator phototesting of 32 normal volunteers who received four different treatment schedules using two different doses of each drug.
The in vitro tests revealed UVA-dep…