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When first released for use, inhaled corticosteroids for allergic or perennial rhinitis and oral corticosteroids for asthma were said to have no topical mucosal or systemic side effects. But recent reports of purpura and dermal thinning in patients using inhaled corticosteroids suggest that there are systemic effects. Now comes a report of acne associated with the use of inhaled beclomethasone dipropionate in four persons with asthma.
The patients ranged in age from 35 to 56, had no prior history of acne, were taking no other drugs known to cause acne, and had recently increased their daily dose of beclomethasone dipropionate to 1000 μg. Four to 12 months before the onset of acne, asthma had become more symptomatic, necessitating an increase…