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Topical tretinoin has been shown to improve features of photoaging in human skin. Although there are dramatic histologic changes in tretinoin-treated photoaged skin, the mechanism by which the drug improves photoaging has not been elucidated. Studies in mice suggest that dermal collagen formation is reduced in photodamaged skin, and that collagen formation is partially restored by treatment with topical tretinoin.
These investigators studied collagen formation in photodamaged skin in humans and the effects of tretinoin. Biopsies were performed on photodamaged and photoprotected skin in 26 untreated subjects and on photodamaged skin in 29 patients before and 10 to 12 weeks after daily application of 0.1% tretinoin cream or vehicle cream. All …