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Concern has been raised about minocycline and its rare but serious association with liver toxicity and lupus erythematosus. To evaluate the safety of high-dose minocycline, researchers in Britain studied 700 patients treated with 100 mg or more per day of minocycline for acne vulgaris. The study population was mostly male (398 patients), had a mean age of 21.6 years, and had been taking minocycline for a mean of 10.5 months. All patients were clinically assessed every 3 months, and 200 were monitored with liver-function tests and blood counts.
Side effects were noted in only 13.6% of patients. The overall rate did not differ significantly with minocycline dose. For most side effects (e.g., GI upset, vestibular dysfunction, and headache), the…