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Adults with acne vulgaris tend to have milder disease than younger persons, but a poorer response to therapy. These investigators observed that adult acne patients are also less tolerant of the side effects of isotretinoin. In an attempt to limit adverse effects and decrease costs, they used an intermittent moderate dose of isotretinoin to treat 80 patients (22 men and 58 women) over the age of 25 years with mild to moderate acne. All patients had either not responded to or relapsed rapidly after three or more courses of oral antibiotic therapy.
Patients were treated with isotretinoin at 0.5 mg/kg per day for 1 week out of every 4, for a total of 6 months. Fasting lipids, liver function, and pregnancy tests were performed before and during t…