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Topical 5-fluorouracil (5-FU) used twice daily for 4 to 6 weeks is known to be highly effective in the treatment of actinic keratoses, but the unsightly and uncomfortable side effects are so dramatic that this treatment is rarely acceptable to patients. Several years ago, a technique of intermittent pulsed topical 5-FU dosing (in which 5-FU is applied twice daily only 1 or 2 days per week) was described and found to be as effective as the traditional regimen with far fewer side effects. This study is the first to independently evaluate pulsed 5-FU treatment.
Thirteen patients were treated twice daily either 1 or 2 days per week for 9 weeks. The results were good or better in five patients, while the remaining patients showed no improvement. …