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Because bacterial infection after laser skin resurfacing significantly compromises the final outcome, many physicians recommend antibiotic prophylaxis. However, no prospective studies have assessed the efficacy of antibiotic prophylaxis. In this small, pilot study of eight consecutive patients undergoing full-face laser skin resurfacing, the first four were not given perioperative antibiotics and the latter four were treated with dicloxacillin beginning two days before surgery (no details of dose or duration were given).
Three of the patients who did not receive perioperative antibiotics grew out 4+ Staphylococcus aureus. Two had localized crusting and pain thought to represent clinical infection, which responded quickly to dicloxacillin. No…