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Polymorphic light eruption (PLE), sometimes termed polymorphous light eruption, is a common, distinct, and benign photodermatosis that predominantly affects young women. It's usually just an annoyance for those affected, but on occasion it can be severe. In this double-blind, controlled study from the U.K., researchers compared prednisolone (equivalent in dose and effect to prednisone) and placebo in 21 patients with PLE of unknown severity.
Patients were supplied with medication to take if they had an acute episode of PLE. They were given 7-day supplies of both prednisolone and placebo and were randomly assigned to begin treatment with 25-mg daily doses of either one. If symptoms did not improve after 48 hours, patients were instructed to s…