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Pityriasis versicolor (PV) responds well to treatment with itraconazole at 200 mg/day for 7 days. Although most patients clear with comparable regimens, most will also experience recurrence within 2 years. To evaluate the efficacy of itraconazole prophylaxis, patients with PV were first treated with 200 mg/day of itraconazole for 7 days, and those that responded were then given prophylactic itraconazole (two 200-mg doses, 12 hours apart) or placebo 1 day per month for 6 months.
Mycologic cure was achieved in 205 of 223 patients who completed the treatment phase (92%). At the end of the 6-month prophylaxis phase, 90 of 102 patients who received itraconazole (88%) and 56 of 99 patients who received placebo (57%) were still mycologically negati…