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Little is known about cold urticaria, an uncommon physical urticaria, in the pediatric population. These authors performed a retrospective chart review to describe 30 children with idiopathic cold urticaria who were treated in the allergy clinic of a children's hospital or in a private allergy practice over a 3-year period. Diagnosis was based on the patient's history and supported by an ice-cube challenge test (17 had a positive response at 10 minutes).
The 17 female and 13 male patients had a median age of 12 years (range, 2.0-18.5 years; median age at disease onset, 7 years). The mean duration of the urticaria was 4 years. The condition was idiopathic in all patients. Blood test results, including measures of cryoglobulins, cold agglutini…