Reclassification using a new system yielded some changes in diagnosis.
The diagnosis and classification of lymphomas are fraught with difficulties. The existence of multiple classification systems (e.g., REAL, WHO, and EORTC) adds to the complexity. A new, combined WHO-EORTC system classifies primary cutaneous B-cell lymphomas as one of three major types: primary cutaneous marginal zone B-cell lymphomas (PCMZL); primary cutaneous follicle center lymphomas (PCFCL); and primary cutaneous large B-cell lymphomas, leg type (PCLBCL-LT).
Researchers retrospectively analyzed 300 patients in the Dutch Cutaneous Lymphoma Group registry whose disease had been diagnosed using EORTC criteria. They reclassified each patient, using immunohistochemical stains when possible, calculating rates of 5-year overall and disease-speci…