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Pigmented purpuric dermatosis (PPD) is characterized by cutaneous petechiae and bronze discolorations located predominantly on the leg, with many clinical variations. The common pathologic pattern of PPD reveals a perivascular lymphocytic infiltrate with red-cell extravasation and presence of hemosiderin. To classify this disorder, the authors prospectively reviewed 43 sequential patients (mean age, 45) with PPD; specifically, they contemplate its inclusion as a cutaneous T-cell lymphoid dyscrasia (CTLD). Clinical, light microscopy, immunophenotype (CD3, CD7, CD62L, and Foxp3), and molecular (PCR assay) analyses were performed and the cases classified as monoclonal PPD (21 patients; 2:1 male) or polyclonal PPD (22; 4:1 male).
The monoclonal …