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An eruption occurring in the third trimester of pregnancy, primarily in primigravid women, was first described in 1979 and given the designation pruritic urticarial papules and plaques of pregnancy (PUPPP). Later investigation linked the syndrome to twin pregnancies and excessive weight gain. Several subsequent studies found greater frequency when the fetus was male, but one other study found greater frequency with female fetal sex. Researchers have suggested that all eruptions of pregnancy be categorized together as polymorphic eruption of pregnancy (PEP).
These authors performed a retrospective, case-control study of 200 pregnancies: 40 women with PEP and 4 matched healthy controls each. The researchers noted a number of factors that were …