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Hyaluronic acid fillers have an excellent long-term safety profile, but local adverse events in the immediate postinjection period are quite frequent. In this industry-sponsored, prospective, blinded, 17-center, controlled study, 283 patients were randomized to receive either Restylane or Perlane hyaluronic acid fillers for nasolabial folds and oral commissures. The injecting investigators used the injection technique that they preferred, and the injection technique and all local adverse events were recorded.
No significant between-filler differences were noted in adverse events. In the pooled data, 20% of patients had bruising, 5% had edema, 4% had tenderness, and 1% had pain after injection. Adverse events mostly resolved by 2 weeks. Local…