Primary Cutaneous Small/Medium CD4⁺ T-Cell Lymphomas: From Indolent to Deadly

T-cell neoplasms that do not fit the diagnostic criteria for the other defined groups in the WHO-EORTC classification system are classified as unspecified primary cutaneous peripheral T-cell lymphomas. Three provisional entities make up this category: primary cutaneous small/medium CD4⁺ T-cell lymphoma (PCSM-TCL), primary cutaneous aggressive epidermotropic CD8⁺ cytotoxic T-cell lymphoma, and cutaneous gamma/delta T-cell lymphoma. These authors describe the clinicopathologic characteristics of PCSM-TCL.

Researchers searched 2 decades’ worth of data from the departments of dermatology and pathology at a single hospital in Spain and identified 32 patients with primary cutaneous peripheral T-cell lymphomas composed predominantly of small- or me…