Estrogen-Related Angioedemas

Novel forms of angioedema are often related to an estrogen trigger.

Two newly described subtypes of angioedema, often estrogen related, occur in women. The closely related conditions resemble angioedema caused by deficiency or dysfunction of the C1 esterase inhibitor (C1-INH). Estrogen-dependent angioedema runs in families and occurs only during pregnancy, oral contraceptive use, or estrogen replacement therapy. A second type, estrogen-associated angioedema, may also be heritable but can occur without obvious estrogen provocation.

Investigators studied four women who experienced attacks of angioedema of the pharynx and limbs. Some episodes were apparently precipitated by local trauma, upper respiratory tract infections, and pregnancy. A maternal aunt of one patient had suffocated during an attack at age 20. …

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)