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Choosing the proper therapy for a palmoplantar pustular (PPP) dermatosis is frequently a clinical challenge. Satisfactory results are seldom realized with any of the available options, including topical and systemic corticosteroids, topical and systemic retinoids, oral dapsone, oral or intramuscular methotrexate, oral colchicine, oral cyclosporine, and topical or systemic psoralen with ultraviolet light (PUVA). Prompted by one prior report of successful itraconazole treatment and this agent’s known anti-inflammatory effects, these authors performed a single-arm, open-label study in six patients. All six were women; had had PPP longer than 6 months; did not have evidence of psoriasis; and were not at the time receiving corticosteroids, photo…