Tailored Moisturizers

Complex moisturizer ingredients not only retain transepidermal water but may also be able to correct specific deficits in barrier function.

Authors of an earlier study that assessed the effects of moisturizers on transepidermal water loss undertook a follow-up study to determine the cellular and molecular effects of these moisturizers.

Twenty healthy volunteers were randomly assigned to apply one of two moisturizers to one side of the body. One moisturizer was a complex formulation of 18 components; the other was a simple oily moisturizer containing mostly lipids, paraffin, and isohexadecane. The moisturizers were applied to one forearm and buttock, twice daily, while the other forearm and buttock served as untreated controls. After 7 weeks, the researchers measured transepidermal water loss, skin capacitance, and blood flow. They provoked irritation at the treated sites by occl…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)