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Bullous pemphigoid (BP) causes subepidermal blisters, urticarial plaques, severe itch, and peripheral blood eosinophilia. It develops when IgG autoantibodies bind to the 180-kD protein antigen (BP180) at the dermal–epidermal junction within the hemidesmosomes of basal cells. Systemic steroids, immunosuppressive agents, and potent topical steroids are first-line treatments for this condition, although occasional patients respond to tetracycline, niacinamide, or dapsone. The disease is often self-limited, and many patients can discontinue treatment, but recurrences are common. It would be nice to know which patients are likely to have durable remission.
In a prospective, cohort study conducted in 15 French dermatology clinics, 118 consecutive …