Cutaneous Clear Cell Sarcoma: Insights from a Rare Entity

The immunoprofiles of CCS and malignant melanoma overlap, so looking for genetic markers is important.

Clear cell sarcoma (CCS) of tendons and aponeuroses (aka malignant melanoma of soft parts) was first described 45 years ago. As the name implies, these lesions frequently affect tendons and aponeuroses of the distal extremities in adolescents and young adults. Both CCS and melanoma involve melanosomes and positivity for the markers S-100, HMB-45, Melan-A, and MITF-1. The authors of this study focus on how the clinicopathologic findings and cutaneous presentation of CCS differ from those of melanoma.

They analyzed 12 cutaneous CCSs with characteristic morphologic findings and fluorescence in situ hybridization (FISH)–proven EWSR1 rearrangement. The patients were predominantly female, with a median age of 25. The most frequent lesion locations…

Reviewing Author

Angelica Selim, MD

Disclosures

Grant / Research support NIH/NCI, The Plastic Surgery Foundation

Angelica Selim, MD

Disclosures

Grant / Research support NIH/NCI, The Plastic Surgery Foundation

Cutaneous Clear Cell Sarcoma: Insights from a Rare Entity

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Reviewing Author