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An association between isotretinoin use and inflammatory bowel disease (IBD) has been suggested. In November 2009, we covered a study by Bernstein and colleagues, which demonstrated no more than a chance association between isotretinoin use and any type of IBD, and a review by Crockett and colleagues, which concluded that a causal association between isotretinoin and IBD had yet to be established. To further evaluate a possible association, some authors of the latter review used a large U.S. database to perform a case-control study comparing isotretinoin use in 8189 patients with incident IBD and 21,832 controls matched for age, sex, and geographic region. The period assessed for pre-IBD diagnosis isotretinoin use was 12 months.
Of the IBD p…