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Until now, no agent or approach has been identified as the treatment of choice for follicular mucinosis. The condition is characterized by localized pink skin and scaling, with alopecia in hair-bearing areas. In about 50% of these patients, skin biopsy specimens show evidence of a clonal T-cell–receptor gene rearrangement. Such a finding can suggest an evolving T-cell lymphoma, especially in patients with lesions in areas beyond the head and neck. Happily, progression to clinical T-cell lymphoma and death is uncommon. However, the plaques tend to persist and do not respond well to treatment with topical steroids.
These investigators report the effects of hydroxychloroquine therapy in six patients with biopsy-proven follicular mucinosis. The …