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Genetic predisposition to psoriasis has been known for many years. Five new genome-wide association studies (GWAS) involving various refinements in technique were conducted in distinct populations. These studies confirm previously identified loci with plausible immunologic importance, including the major histocompatibility complex (MHC) class I alleles, such as HLA-C and the cytokines interleukin (IL)-12 and IL-23, as well as identifying new loci.
The Genetic Analysis of Psoriasis and Wellcome Trust Case Control consortia studied subjects of European ancestry in the U.K. and Ireland (594,224 SNPs in 2622 cases and 5667 controls). They identified new loci, including TYK2, which regulates inflammatory cytokine production, and ERAP1, which regu…